Ayurvedic herbs are a crucial part of the system. Ayurvedic herbs are typically used by practitioners to cleanse the body, support the immune system against illness, and maintain harmony between the body, mind, and spirit.
About Digitalis Lanata
A type of foxglove called Digitalis lanata is also referred to as woolly foxglove or Grecian foxglove. The entire plant of Digitalis lanata, like certain other foxglove species, is poisonous. When digitalis toxicity reaches a critical level, symptoms of poisoning include nausea, vomiting, dilated pupils, a strong headache, blurred vision, and convulsions. It is regarded as a noxious weed in some situations. Digitalis lanata is a perennial plant that is always in the leaf, blooms in the months of June and July, and produces ripe seeds in early to mid-September.
Uses of Digitalis Lanata
- Auricular fibrillation and cardiac heart failure are both treated with digitalis. In addition, it has a variety of other conventional uses.
- Digoxin and Lanatoside are both made from leaves.
- Since lanatoside C has a lessened cumulative effect, it is useful in long-term therapy.
Categorization
Kingdom: Plantae
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Lamiales
Family: Plantaginaceae
Genus: Digitalis
Species: D. lanata
Binomial Name: Digitalis lanata
Synonym: Digitalis orientalis, Digitalis nova
Morphology
The height of the plant typically ranges from 13 to 26 inches, or roughly 0.3 to 0.6 meters. The plant prefers humus-rich soil and some shade. Also preferred by the plant are loamy, sandy, and clay soils. It may also flourish in both dry and humid environments.
1. Seeds
Small hook-shaped pods hold the seeds as they mature. These pods can be moved by wearing or wearing animal fur.
2. Leaves
The tall, woolly, veined, and bottom-wrapped leaves have a mid-green color and are covered in white hairs. The taste of these leaves is extremely harsh.
Taste: Bitter in taste.
Shape: Linear, sessile, and lanceolate.
3. Flowers
Bell-shaped and tubular blooms are seen. They have purplish-brown and creamy-white coloring. Normal flower growth occurs in the second year. Hairy stems and flowers are both present.
Geographical Source
In India, Holland, and North America, the plant is cultivated, but it grows wild throughout Europe.
Medicinal Properties
Cardiovascular
Cytotoxic
Neuroprotective
Cardioprotective
Parts Used
The plant's medicinal component is the leaves.
Dosage
Since the digitalis leaf has a limited therapeutic index, constant medical supervision is necessary for use that is safe. The recommended starting dose is 1.5 g of a leaf, administered twice a day in separate doses. The daily intake of pure digoxin ranges from 0.125 to 0.25 milligrams.
Chemical Constituents
It is a source for the creation of digoxin and other glycosides and is more potent than Digitalis purpurea. While others are present in Digitalis purpurea, digoxigenin and dignatigenin are exclusive to Digitalis lanata.
The chemical components of Digitalis lanata include:-
- Digitoxin, gitoxin, and digoxin.
- Lanatoside A, B, C, D & E.
- Lanatoside is an acetylated product of purpurea glycosides.
- Flavones derivatives like scutellarein, dinatin, etc.
Health Benefits
A potent cardiac glycoside found in digitalis lanata has good isotropic effects because it inhibits sodium-potassium adenosine triphosphatase, allowing calcium to build up in myocytes and improving cardiac contractility. Patients with heart issues might utilize that.
Digitalis lanata is used to make digoxin (digitalin). Some heart conditions like atrial fibrillation are treated with it. It lessens atrioventricular conduction, slowing the heartbeat and marginally enhancing contraction force. Congestive heart failure patients have better circulation, which allows the kidneys to function normally, stimulates urine flow, lowers blood volume, and lessens the strain on the heart. Although some medications have antiarrhythmic properties as well, greater doses will result in arrhythmias.
Some in-vitro and screening investigations have demonstrated the cytotoxic activities of the glycosides and flavonoids from the Digitalis lantana and Digitalis purpurea. These demonstrate their efficacy against solid tumor lines and human cancer cell lines. The direct cytotoxicity of Digitalis lanata, which induces apoptosis, the suppression of nitric oxide synthase activation, the prevention of aflatoxin-induced cytotoxicity, and elevations in glutathione S-transferase levels are just a few of the ways it fights cancer.
Studies on animals demonstrate that Digitalis lanata has a favorable impact on lipid profile. Even two hours after receiving a single dose of the saponin digitonin, hyperglycemic and dyslipidemic rats displayed improved glucose tolerance.
Other than treating heart conditions, Digitalis lanata is also used commercially. For instance, the powdered leaves of Digitalis lanata are used as sedatives, diuretics, and to treat asthma in South America. It is also utilized in India as an ointment for burns and wounds that contain digitalis glycosides.
Contraindications
- The use of Digitalis lanata is contraindicated in children because this plant is a potentially lethal plant.
- The use of this plant is also avoided at the time of pregnancy and lactation because it may show negative effects.
Interactions
Digitalis glycosides and digoxin interact in a variety of ways. Negative consequences of combining Digitalis lanata with several medications have been observed, and they can range from minor to life-threatening. Cimetidine and triamterene are two medications that have minimal effects when used with Digitalis lanata. When Digitalis lanata is administered along with several medications, such as amiodarone, cyclosporine, macrolide and tetracycline antibiotics, propafenone, quinidine, verapamil, and diuretics, elevated digoxin serum levels or electrolyte abnormalities frequently arise.
Adverse Drug Reactions
Toxicity is typically a factor in Digitalis lanata adverse effects. In order to utilize Digitalis Lanata safely, full-time physician supervision is needed.
Toxicology
This plant is poisonous in every aspect. By eating the seeds or leaves or inhaling the blossoms, children have had health problems. Additionally, it becomes life-threatening for those who unintentionally drink Digitalis tea. Although the bitter taste frequently discourages intake and its emetic effects can cause vomiting, this can reduce the amount of substance that is absorbed by the body.
Intoxications during treatment are common because of the very slow buildup and excretion of digitalis glycosides. The incidence of therapeutic overdose is decreased by following the right dosing instructions and keeping track of the patient for safe use.
Contracted pupils, blurred vision, frequent urine, exhaustion, dizziness, muscle weakness, a strong yet delayed pulse, nausea, and vomiting are all symptoms of refined drug or plant toxicity. Confusion, convulsions, stupor, and even death are possible in severe situations.